Abstract
This paper describes a simple, rapid, and effective quality assessment method for Fructus Schisandrae by gas chromatography-mass spectrum (GC-MS). The method was established by using specific lignan fingerprint profiles and quantitation of characteristic compounds in this herbal medicine. The GC-MS fingerprints of 15 batches of Schisandra samples from different regions of China showed similar lignan profiles. Five peaks were selected as characteristic peaks, and all of these were identified by using GC-MS techniques. The relative retention times of these characteristic peaks in the GC-MS fingerprint were established as an important parameter for identification of Schisandra samples. Meanwhile, relative peak areas may be a feasible approach to discriminate the S. chinensis and S. sphenanthera. Finally, these pharmacologically active constituents in the titled plant, schisandrins A–C and schizandrols A and B, were quantitatively determined using a validated GC-MS method.
Highlights
Traditional Chinese Medicines (TCMs) have made great contribution to the health of Chinese people for thousands of years due to its special clinical efficacy [1]
In terms of quantitative analysis of S. sphenanthera and S. chinensis, many analytical methods have been reported for the determinations of lignans, including HPLC with UV detection, HPLC with mass spectrum (HPLC-MS), and capillary electrophoresis (CE) [9, 15,16,17,18,19,20]
The usage of larger volume of solvent for extraction is able to obtain higher yields. This result was special, and the same circumstance was found for ultrasound-assisted extraction of phillyrin from Forsythia suspensa [26]
Summary
Traditional Chinese Medicines (TCMs) have made great contribution to the health of Chinese people for thousands of years due to its special clinical efficacy [1]. In recent years, there is an increasing trend to establish multicomponents analysis for the effective quality control of TCMs [4,5,6]. Quantitative analysis of multiple-lignans in Fructus Schisandrae is very essential to control its quality. In terms of quantitative analysis of S. sphenanthera and S. chinensis, many analytical methods have been reported for the determinations of lignans, including HPLC with UV detection, HPLC with mass spectrum (HPLC-MS), and capillary electrophoresis (CE) [9, 15,16,17,18,19,20]. The newly established method was utilized to analyze 15 samples collected from different regions of China
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
