Abstract
Uncoupling activity with spinach thylakoids was measured for a series of acidic uncouplers related to the most potent uncoupler known until now, SF6847 (2,6-di- t-butyl-4-(2,2-dicyanovinyl)phenol). The activity of each compound with thylakoids was lower than that measured previously with rat-liver mitochondria. The two kinds of uncoupling activity were both linearly related to protonophoric potency across the liposomal membrane if the effect of the stability of the ionized form of the uncouplers in the membrane phase was considered. The difference in the apparent uncoupling activity between the two systems may be attributed to a difference in the intrinsic uncoupling activities at the phosphorylation assemblies. The results provided further evidence for the shuttle-type mechanism of weakly acidic uncouplers.
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