Abstract
Two selective spectrophotometric methods are described for the assay of tolnaftate in single and/or combined pharmaceutical formulations. The first one depends on the formation of a methylene blue dye (λmax 665 nm) by the reaction of N,N-di-Me p-phenylene diamine dihydrochloride in the presence of ceric ammonium sulfate with sodium sulfide resulting from the alk. hydrolysis of the thiono ester-tolnaftate. All variables affecting hydrolysis of tolnaftate were studied. Also other parameters affecting the color development as sulfuric acid and reagent concns., reaction time, temp. and diln. solvents were optimized. The second method depends on the simultaneous estn. of tolnaftate and clioquinol in the presence of gentamycin sulfate and betamethasone by the measurement of the first deriv. spectrum in
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