Abstract
THE existence of adrenaline (A) in the mammalian central nervous system (CNS) was first demonstrated by von Euler1 and Holtz2. Subsequently, many reports have documented the presence of whole brain A in mammals and amphibia. In amphibia adrenaline is the major CNS catecholamine3, being about four times greater than noradrenaline4, while in mammals, adrenaline is only a small fraction (4–22%) of the total noradrenaline content5,6. These data in mammals could indicate either adrenaline uptake from the periphery or a very discrete adrenaline pathway possibly with a high turnover rate. We have quantitatively measured adrenaline in some specific nuclei of the rat brain, using the highly sensitive and specific technique of gas chromatography–mass spectrometry (GC–MS)7.
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