Abstract
We have previously described the application of proton therapy for midline central nervous system (CNS) tumors, using from 1 to 5 midline sagittal beams to target superficial and deep seated tumors while sparing the hippocampi and temporal lobes. In our previously reported cohort, the number of beams used was driven by individual physician judgment, balancing improved dose conformality against the cost of increased integral brain dose. We sought to build a model of proton treatment to quantify the competing demands of conformality and integral dose in an effort to identify the optimal number of beams in this technique.
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