Abstract
There is a need for objective, sensitive, and reproducible methods of assessing skin sclerosis. We successfully adapted ultrasound-based, noninvasive methods for quantifying tissue stiffness for use on the skin: acoustic radiation force impulse (ARFI) imaging and shear wave elasticity imaging (SWEI) (Lee et al., 2015). ARFI imaging generates images of micron-scale tissue displacement, whereas SWEI measures the speed at which sound waves travel across target tissue (shear wave speed [SWS]) in meters per second (Palmeri and Nightingale, 2011).
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