Abstract
Summary Diffuse myocardial fibrosis in hypertensive left ventricular hypertrophy (LVH) is not readily detected by conventional late gadolinium enhanced CMR. Our study was aimed to detect diffuse myocardial fibrosis in these patients as compared to age matched normal controls, using a T1 mapping technique. Fibrosis was quantified by calculating the partition coefficient (l) and volume of distribution (Vd) of gadolinium (Gd) following a bolus injection of Gd. We observed that the values for l and Vd were higher in LVH than controls. A positive association was also noted between LV mass and l. Background
Highlights
Diffuse myocardial fibrosis can occur in hypertensive left ventricular hypertrophy (LVH) and is not readily detected by conventional late gadolinium enhanced CMR
Fibrosis was quantified by calculating the partition coefficient (l) and volume of distribution (Vd) of gadolinium (Gd) following a bolus injection of Gd
We observed that the values for l and Vd were higher in LVH than controls
Summary
Diffuse myocardial fibrosis can occur in hypertensive left ventricular hypertrophy (LVH) and is not readily detected by conventional late gadolinium enhanced CMR. We previously described a shortened Modified Look-Locker Inversion Recovery (3-5 MOLLI) T1-mapping technique which can quantify fibrosis by calculating the partition coefficient (l) and volume of distribution (Vd) of gadolinium (Gd) following a bolus injection of Gd.[1]. We hypothesized that this technique could detect fibrosis in subjects with hypertensive LVH and normal ejection fraction. This could have important implications for assessment of diastolic heart failure and to monitor benefits of anti-fibrotic, anti-hypertensive therapy. We aimed to detect diffuse myocardial fibrosis in hypertensive patients with LVH as compared to age matched normal controls
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
