Quantification Of Viral Genomes In Immunocompromised Patients

Abstract

The increasing prevalence of immunocompromised patients in Tunisia is due to the (1) immunosuppressive chemotherapy advances, (2) implantation of a national centre for bone marrow transplantation and (3) progressing number of HIV infected patients. Numerous infectious agents threaten these patients causing a significant morbidity often leading to hospitalisation in critical care settings. The monitoring of immunocompromised patients by molecular tools allows to reduce this morbidity and improve their life quality. In this study, we have routinely performed sequential quantification of CMV in transplant recipients since 1997 and the quantification of HIV-RNA in HIV infected patients since 2000.