Year-end Sale % OFF 
Abstract
BackgroundThe study quantified the relative contributions of estrogen (E2) and total testosterone (TT) to variation in bone mineral density in men and women.MethodsThis was a cross-sectional study which involved 200 men and 415 women aged 18 to 89 years. BMD at the lumbar spine (LS) and femoral neck (FN) was measured by DXA. Serum levels of E2 and TT were measured by electrochemiluminescence immunoassays. The association between E2, TT, and BMD was analyzed by the multiple linear regression model, adjusting for age and BMI. The contribution of each hormone to the variation in BMD was quantified by the bootstrap method.ResultsIn women, higher serum levels of E2, but not TT, were significantly associated with greater BMD at the FN (P = 0.001) and LS (P < 0.0001). In men, higher serum levels of E2 were independently associated with greater FNBMD (P = 0.008) and LSBMD (P = 0.086). In the multiple linear regression model, age, body weight and E2 accounted for 50-55% variance in FNBMD, and 25% (in men) and 48% (in women) variance in LSBMD. Variation in E2 accounted for 2.5% (95% CI 0.4 - 7.8%) and 11.3% (95% CI 8.1 - 15.3%) variation in FNBMD in men and women, respectively. Moreover, E2 contributed 1.2% (95% CI 0.1 - 5.8%) and 11.7% (95% CI 8.5 - 15.9%) variation in LSBMD in men and women, respectively.ConclusionsEstrogen is more important than testosterone in the determination of age-related bone mineral density men and women of Vietnamese background. However, the relative contributions of estrogen to bone mineral density in men are likely modest.
Highlights
The study quantified the relative contributions of estrogen (E2) and total testosterone (TT) to variation in bone mineral density in men and women
The two men had low bone density as initially reported by Smith et al.; when the men were treated with estrogen, their bone mineral density (BMD) increased
Analysis of relative importance Relative importance analysis (Table 3) shows that variation in serum levels of estradiol “explained” 2.5% of variance in femoral neck BMD
Summary
The study quantified the relative contributions of estrogen (E2) and total testosterone (TT) to variation in bone mineral density in men and women. Deficiency of estrogen leads to increased bone loss, lower bone mineral density (BMD), and increased fracture risk [1]. The two men had low bone density as initially reported by Smith et al.; when the men were treated with estrogen, their BMD increased. These cases have demonstrated that estrogen does play an important role in the skeletal maturation and mineralization in men, and changes the traditional view that estrogen is a “female hormone”
Sign-in/Register to view highlights & summary 
Published Version (
Free)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
