Quantification of the efficiency of magnetic targeting of nanoparticles using finite element analysis

Abstract

The lack of efficient drug delivery to tumor cells has led to investigations into the administration of magnetic drugs, which use magnetic fields to target treatment to specific organs, thereby reducing side effects compared to traditional treatments. The dynamics of MTD in breast arteries are currently unknown and can be modeled using second-order differential equations. Blood flow is generally assumed to be a non-Newtonian fluid due to its viscosity characteristics. In this study, we modeled the targeting efficiency of magnetic nanoparticles with sizes of 50 nm, 100 nm, and 200 nm under a constant magnetic field of 0.12 T using a computational tool based on the finite element technique. Our results showed that magnetic nanoparticle targeting efficiency was highest with simulated magnetic fields located 5 cm, 7.5 cm, and 15 cm away from the tumor when using nanoparticles of 50 nm and 100 nm.