Abstract
Fifteen rabbits were used to assess the effect of Lipo-PGE1 on neovascularization. Merocel(®) and Alloderm(®) of the same size were implanted separately under the back skin to act as matrices for vessel growth. Lipo-PGE1 was injected intravenously for 2 weeks in an experimental group of eight rabbits, and they were compared with a control group of seven untreated animals. Blood flow was measured using the (99m)TcO4(-) clearance technique. The mean blood clearance halftime (T1/2) and washout radioactivity were measured. Newly formed vessels were counted by CD31. The mean clearance halftime was 4005±2161.3 and 13840±4644.6s in the experimental and control group, respectively, in the 1×2×1.5-cm-sized implants (p=0.0125), and 1560±1174.7 and 3405±807.03s, respectively, in the 2×2×1.5-cm-sized implants (p=0.0413). Histological examinations revealed that the mean numbers of newly formed vessels in the experimental and control groups were 11±1.58 and 7.8±1.71, respectively, in the 1×2×1.5-cm-sized implants (p=0.0501), and 20.19±12.47 and 12.33±3.25, respectively, in the 2×2×1.5-cm-sized implants (p=0.02679). Lipo-PGE1 was found to be effective in promoting angiogenesis in a rabbit matrix model.
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