Quantification of the Effect of Excipients on Bioavailability by Means of Response Surfaces III: In Vivo-In Vitro Correlations

Abstract

This study compares one of the previously studied formulations with commercial amoxicillin capsules. The results indicate that the percentage of the dose absorbed is similar in both formulations; nevertheless, the amoxicillin capsules present a higher absorption rate. The in vivo-in vitro correlations in terms of response surfaces, and the general correlation among all the formulations studied in the three articles of this series is discussed. The quantity of drug excreted in 2 hr and the quantity of drug dissolved in 30 min presents a correlation coefficient r = 0.9458 (p < 0.01) and the quantity of amoxicillin excreted in 12 hr and the quantity dissolved in 180 min presents a correlation coefficient r = 0.9761 (p < 0.01).