Quantification of neonatal cerebral ventricular volume by real-time ultrasonography. Derivation and in vitro confirmation of a mathematical model.

Abstract

The derivation and in vitro confirmation of a method for the calculation of cerebral ventricular volume determined by cranial ultrasonography is described. The derivation depends on use of the cylindrical coordinate method. Confirmation was performed by construction of ultrasound phantoms from latex balloons embedded in a talc/gelatin matrix. Seventeen phantoms of volumes ranging from 10 to 60 mL were measured. The known volume was then compared to the calculated volume by linear regression analysis. The regression analysis indicated a close correlation between the actual volume of the phantoms and the calculated volume with r = 0.96. Various sources of error in the method are discussed. Our results indicate that the cylindrical coordinate mathematical model when applied to cranial ultrasonography images accurately measures cerebral ventricular volumes.