Abstract
Introduction Myocardial perfusion MRI is a useful modality to detect myocardial ischemia. Quantitative perfusion estimates require an accurate arterial input function (AIF). Recently, a method for estimating T1 and thus gadolinium concentration from a radial k-space perfusion sequence was proposed [1]. The method created four sub-images with differing effective saturation recovery times (eSRTs) from 96 ray acquisitions to estimate T1. No measures of truth were used to evaluate the method in vivo. In this work, we employ a similar technique for obtaining T1 estimates and compare to perfusion estimates from a dual-bolus method, a current standard for quantifying myocardial perfusion [2].
Highlights
Myocardial perfusion MRI is a useful modality to detect myocardial ischemia
We employ a similar technique for obtaining T1 estimates and compare to perfusion estimates from a dual-bolus method, a current standard for quantifying myocardial perfusion [2]
Perfusion MRI studies were performed on Siemens 3 T Trio and Verio systems. 12 subjects (8 female, 4 male) without ischemia were given a low dose (0.004 mmol/kg) of dilute (1/5 concentration) contrast agent (CA: GdBOPTA) and a higher non-dilute dose (0.02 mmol/ kg)
Summary
Myocardial perfusion MRI is a useful modality to detect myocardial ischemia. Quantitative perfusion estimates require an accurate arterial input function (AIF). A method for estimating T1 and gadolinium concentration from a radial k-space perfusion sequence was proposed [1]. The method created four sub-images with differing effective saturation recovery times (eSRTs) from 96 ray acquisitions to estimate T1. No measures of truth were used to evaluate the method in vivo. We employ a similar technique for obtaining T1 estimates and compare to perfusion estimates from a dual-bolus method, a current standard for quantifying myocardial perfusion [2]. A 2-compartment model was used to determine Ktrans
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