Quantification of isocyanates and amines in polyurethane foams and coated products by liquid chromatography-tandem mass spectrometry.

Motoh Mutsuga,Miku Yamaguchi,Yoko Kawamura

doi:10.1002/fsn3.88

Motoh Mutsuga, Miku Yamaguchi + Show 1 more

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https://doi.org/10.1002/fsn3.88

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Abstract

An analytical method for the identification and quantification of 10 different isocyanates and 11 different amines in polyurethane (PUR) foam and PUR-coated products was developed and optimized. Isocyanates were extracted and derivatized with di-n-butylamine, while amines were extracted with methanol. Quantification was subsequently performed by liquid chromatography–tandem mass spectrometry. Using this methodology, residual levels of isocyanates and amines in commercial PUR products were quantified. Although the recoveries of certain isocyanates and amines were low, the main compounds used as monomers in the production of PUR products, and their decomposition species, were clearly identified at quantifiable levels. 2,4-and 2,6-toluenediisocyanate were detected in most PUR foam samples and a pastry bag in the range of 0.02–0.92 mg/kg, with their decomposition compounds, 2,4-and 2,6-toluenediamine, detected in all PUR foam samples in the range of 9.5–59 mg/kg. PUR-coated gloves are manufactured using 4,4′-methylenebisphenyl diisocyanate as the main raw material, and a large amount of this compound, in addition to 4,4′-methylenedianiline and dicyclohexylmethane-4,4′-diamine were found in these samples.

Highlights

Polyurethane (PUR) is obtained from the chemical reaction between diisocyanates and polyols
In Regulation (EU) No 10/2011 (EC 2011), 14 aliphatic and aromatic isocyanates are listed as monomers and other starting substances that are authorized for the manufacture of plastic materials and articles that are intended to come into contact with foodstuffs
The PUR-coated products consisted of two types of nylon fiber glove that were coated with PUR on the palm side, and one polyester pastry bag that was coated with PUR on one side

Summary

Introduction

Polyurethane (PUR) is obtained from the chemical reaction between diisocyanates and polyols. Most PUR products contain 2,4- or 2,6-toluenediamine (2,4- or 2,6-TDA) or 4,4′-methylenedianiline (4,4′-MDA) (Colleen et al 1985; Inoue et al 1985; Hull et al 1989; Lawson et al 1996). In Regulation (EU) No 10/2011 (EC 2011), 14 aliphatic and aromatic isocyanates are listed as monomers and other starting substances that are authorized for the manufacture of plastic materials and articles that are intended to come into contact with foodstuffs. Their residual limit in the finished articles is 1.0 mg/kg, expressed as the isocyanate function (NCO) (EC 2011)

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