Abstract
Summary. Eight XYY men were investigated by a quantitative, histological analysis of the seminiferous epithelium. All but one had testes of normal size. Biopsy material from three men showed normal spermatogenesis, while severe impairment was found in a substantial number of the tubules in biopsies from five of the patients. The abnormalities included arrest of spermatogenesis at the primary spermatocyte level and tubules containing only Sertoli cells. These results correlate well with sperm counts which range from normal numbers to total aspermia. Normal plasma levels of gonadotrophins were found in five of the six subjects examined; one of the six had a significantly increased level of FSH and another, an increased level of LH.
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