Abstract
Background Renal Denervation (RDN) is a novel therapy for patients with resistant hypertension. Its cardiac effects at followup are currently unknown. On the other hand, T1 mapping permits the assessment of myocardial extracellular volume (ECV), a parameter proposed to quantify diffuse myocardial fibrosis and independently associated with mortality and hard cardiovascular events. Our aim was to study the effects of RDN on ECV at 6-month follow-up. Methods 14 patients with resistant hypertension undergoing RD (RD group) and 4 resistant hypertensive patients not undergoing RD (control group) were prospectively included. A 1.5T cardiac MR including T1 mapping preand post-contrast was performed before the RD procedure and at 6-month follow-up in both groups. Blood hematocrit was determined at both time points. Images were post-processed using commercial software (Qmass, Medis
Highlights
Renal Denervation (RDN) is a novel therapy for patients with resistant hypertension
No significant differences in whole LV extracellular volume (ECV) or septal ECV were observed between baseline and 6-month follow-up in the RD group
Control patients presented an increase in whole LV ECV and septal ECV at 6-month follow-up which did not reach statistical significance (p = 0.14 and p = 0.11, respectively)
Summary
Adelina Doltra1*, Jan-Hendrik Hassel, Daniel Messroghli, Bernhard Schnackenburg, Philipp Stawowy, Rolf Gebker, Christopher Schneeweis, Alexander Berger, Eckart Fleck, Sebastian Kelle. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. From 17th Annual SCMR Scientific Sessions New Orleans, LA, USA. 16-19 January 2014
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