Abstract
Objective The aim of this study was to investigate the possibility of type 2 vesicular monoamine transporter molecular probe, 18F-FP-(+ )-DTBZ, in the monitoring of total islet β cell mass in animal models. Methods Two groups of Wistar rats were included in this study. In the type 1 diabetes group (n=6), the streptozotocin (STZ) was intraperitoneally injected at a dose of 65 mg/kg, and the control group (n=6) was likewisely injected with an equal volume of saline, Micro- positron emission tomography (PET)/ computed tomography (CT) imaging was performed at these rats post injection of18F-FP-(+ )-DTBZ at 0.5, 1, 4, 6, and 12 months after STZ or saline injection, bodyweight and glucose level were also measured. Results The average standardized uptake values (SUV) in the pancreas in the type 1 diabetes rats were decreased significantly than that of the control group at 0.5, 1, and, 4 months (P 0.05) post injection of STZ and saline. Fasting blood glucose positively correlated with pancreatic SUV in the two groups at 0.5, 1, and 4 months (P<0.05) post injection of STZ and saline. Conclusion 18F-FP-(+ )-DTBZ PET imaging is a promising method for dynamic monitoring β cell mass in type 1 diabetic rats. Key words: Diabetes mellitus; Positron emission tomography; βcell mass; Type 2 vesicular monoamine transporter
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