Quantification of amyloid accumulation and glucose metabolism in Chinese Alzheimer’s disease population

Abstract

AbstractBackgroundExtracellular amyloid‐β (Aβ) neuritic plaques, intracellular neurofibrillary tangles (NFTs) and neurodegeneration, such as glucose hypometabolsim were the main biomarkers of Alzheimer’s disease (AD). The uptakeof Aβ radiotracers, such as Flortabetapir, and uptake of FDG for glucose metabolism in subjective cognitive decline (SCD), mild cognition impairment (MCI) and Alzheimer’s disease (AD) is very important for diagnosis and management. Currently, no study was found to investigate the uptake of Flortabetapir and FDG in these cohorts. In this study, we try to figure out the standard uptake value ratio (SUVr) of different brain regions in Chinese SCD, MCI, AD.Methods93 normal cognition (NC) healthy volunteers, 37 SCD, 34 MCI and 36 AD patients were enrolled in this study. 3 cognitive domains (2 neuropsychological tests of each domain) and MMSE, Moca B were performed in these participants. FDG and 18F‐Flortabetapir were conducted in these participants. 18F‐FDG and 18F‐FlortabetapirPET images were coregistered to the individual structural MRI images and then spatially normalized into MNI space. SUVr values were calculated with cerebellum as referencefor Flortabetapir and whole brain for FDG.ResultsIn Chinese NC, SCD, MCI and AD, SUVr of flortabetapir in precuneus were 0.87 ± 0.25, 0.84 ± 0.18, 0.83 ± 0.32, 1.08 ± 0.46, respectively. 1.09 ± 0.24, 1.02 ± 0.15, 1.05 ± 0.28, 1.24 ±0.38 in posterior cingulate. SUVr of flortabetapir in AD is significant higher (p < 0.05) than other groups. SUVr of FDG in precuneus were 1.17 ± 0.08, 1.19 ± 0.07, 1.13 ± 0.12, 1.07 ± 0.10, 1.05 ± 0.10, respectively. 1.08 ± 0.10, 1.03 ± 0.12, 0.90 ± 0.18 in posterior cingulate. SUVr of FDG in AD is significant lower (p < 0.05) than other groups.ConclusionThe uptakes of Flortabetapir were signifigant higher and uptakes of FDG were lower in Chinese AD than in NC, SCD, MCI in precuneus and posterior cingulate.