Abstract
Summary Hepatitis B surface antigen (HBsAg) is usually used as a qualitative marker for the diagnosis of hepatitis B virus (HBV) infection, ant its persistence for more 6 months defines chronic hepatitis B (CHB) infection. HBsAg quantification was introduced several years ago. Commercial quantitative assays are now available and studies have suggested its interest for the monitoring patients with chronic hepatitis B. Indeed, HBsAg titers can correlate with intrahepatic cccDNA levels. Several studies have shown that HBsAg titers vary in the different phases of the natural history of the CHB infection. The kinetic of serum HBsAg seems to have a predictive value of HBsAg clearance after treatment or of reactivation, in the case of lack of response to treatment. However, interpretation has to take into account the phase of CHB infection, the HBV genotype, HBeAg status and serum HBV DNA.
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