Abstract

Non-contact detection schemes for optical or fluorescence tomography offer several advantages compared to classic approaches, most importantly the ability to obtain images with a CCD in the absence of a matching fluid or fiber optics. This allows the acquisition of high density datasets, as well as simplified experimental procedures. Herein we create a unified framework for contact and non-contact detection procedures and present experimental results that show the ability of the non-contact method to quantify the concentration of fluorochromes hidden in turbid media as well as the improvement in image quality between conventional and non-contact detection.

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