Abstract
AbstractA 70-year-old patient consulted his general practitioner for asthenia evolving for two weeks, associated with slight edema of the lower limbs. A first biological assessment showed acute organic renal failure associated with a nephrotic syndrome with hypogammaglobulinemia. In the presence of this hypogammaglobulinemia, a monoclonal constituent (whole immunoglobulin or free light chains-FLC) is suspected and was found to be positive with the detection of monoclonal FLC lambda. This clinical and biological picture being in favor of amyloidosis, during the patient’s hospitalization, a renal biopsy is performed. The staining of the biopsy with Congo Red was positive and the typing reveals amyloid deposits of monoclonal lambda FLC. With these clinico-biological arguments, a diagnosis of AL amyloidosis is confirmed.
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