Quality of sleep in adult patients with cystic fibrosis

Abstract

<b>Introduction:</b> Although patients with Cystic Fibrosis (CF) complain about sleep disorders, limited research has been made about their quality of sleep. <b>Aims and objectives:</b> To study sleep disorders in patients with CF in correlation with their lung function. <b>Methods:</b> Stable adult patients with CF were included and answered the following sleep related questionnaires: Epworth Sleepiness Scale (ESS), Fatigue Severity Scale (FSS), Pittsburgh Sleep Quality Index(PSQI) and Athens Insomnia Scale(AIS). The Kerem questionnaire was also completed, evaluating the quantity of cough. Pulmonary lung function testing was performed. <b>Results:</b> 18 adult patients with CF (13 men and 5 women) in a stable condition were included in this study aged 30.17 ± 7.2 years. Their mean FEV1 was 58.93 ± 25.07 % of predicted, their FVC 75.37 ± 26.14 % of predicted, their FEV1/FVC 62.80 ± 12.39 % of predicted and oxygen saturation (SaO2%) 95.2 ± 2.6%. The average score of ESS was 6.61 ± 3.05, of FSS 25.29 ± 11.20, of PSQI 5.06 ± 4.15 and of AIS 4.39 ± 4.67. There was a strong and statistically important correlation between FEV1 and ESS score (p= 0.04), between SaO2% and PSQI score(p=0.03), as well as between Kerem (nighttime) and AIS (p=0.008) and PSQI score (p=0.001). <b>Conclusion:</b> Although there was a small number of participants, no significant disorder in sleep quality among stable patients with CF based on questionnaires was noted. However, a correlation between lung function, nighttime symptoms and sleep quality was found.