Quality of life in patients with symptomatic multivessel coronary artery disease: ten-year follow-up of a comparative post hoc analyses of medical, angioplasty or surgical strategies-MASS II trial

Abstract

Background: The effects of coronary interventions on quality of life (QoL) among patients with CAD are still scarcely studied. We evaluated the impact of CABG, PCI or Medical Therapy (MT) on self-perceived QoL among stable CAD patients, participants of MASS II trial. Methods: The Short-Form Health Survey (SF-36 QoL) was applied and the analysis was made at baseline, 5 and 10 years. The questionnaire was administered to 611 patients randomized to 3 treatment options at baseline, 401 patients after 5 years and 334 after 10 years (110 were initially assigned to CABG, 126 to PCI, and 98 to MT). Multiple comparisons were carried out. The data was presented by dimensions and also separated in mental and physical parameters. Results: In this study, after ten years of follow-up, 148 patients (47.3%) had AMI, 97 (25.9%) underwent CABG or PCI, 16 (4.8%) had stroke, and 293 (87%) had angina. At baseline, the physical component of CABG patients presented the worst condition compared with PCI or MT. Regarding the mental component, there was no statistical difference between treatment groups at baseline, five and ten years. On the other hand, in MT patients they scored in the mental component 63, 75 and 78, and in the physical component 54, 73 and 72, respectively at baseline, 5 and 10 years. In CABG patients, the mental component was 59, 79 and 74, and in the physical component 46, 77 and 69, respectively. In the PCI arm, the mental component scored 64, 68 and 76 and in the physical component scored 57, 71 and 77, at baseline, 5 and 10 years. ![Figure][1] Figure 1 Conclusion: Improvement was observed in all dimensions and in the 3 therapeutic options in 5 years and that persisted in 10 years. Comparatively, CABG provided a better QoL in the first 5 years and that persisted in 10-year follow-up. [1]: pending:yes