Abstract
BackgroundDisease and treatment related events, can adversely affect the quality of life of patients with cancer. The purpose of this study was to translate and validate a gastric cancer specific health related quality of life questionnaire (EORTC QLQ-STO22) for Iranian patients suffering from gastric cancer.MethodsForward-backward procedure was applied to translate the English language version of the EORTC QLQ-STO22 into Persian (Iranian language). Then, the questionnaire and the EORTC core quality of life instrument (QLQ-C30) were administered to a sample of patients with confirmed diagnosis of gastric cancer. All patients filled in questionnaires before and after one month of treatment. Patients were divided into two groups based on intension of treatment (curative vs. palliative). Reliability and validity of the module was tested by internal consistency and known group comparisons, respectively.ResultsIn all, 105 patients were entered into the study. Cronbach's alpha for multi-item scales (to test reliability) ranged from 0.54 to 0.87. The questionnaire discriminated well between clinically distinct subgroups of patients both before and after treatment lending support to its convergent and clinical validity.ConclusionOverall, the Iranian version of the EORTC QLQ-STO22 demonstrated a good reliability and clinical validity to support its use in combination with core questionnaire in outcome studies of gastric cancer in Iran. However, using the QLQ-STO22 in a wide range of Iranian patients with gastric cancer should allow further confirmation for its psychometric properties.
Highlights
Disease and treatment related events, can adversely affect the quality of life of patients with cancer
Quality of life in patients with gastric cancer is increasingly added as outcome measure in clinical research, it is argued that quality of life assessments in these patients deserve more systematic studies using gastric cancer specific instruments
In assessing quality of life in cancer patients it is recommended that to use a cancer-specific questionnaire as a general measure of quality of life in cancer patients plus site-specific modules
Summary
Disease and treatment related events, can adversely affect the quality of life of patients with cancer. The purpose of this study was to translate and validate a gastric cancer specific health related quality of life questionnaire (EORTC QLQ-STO22) for Iranian patients suffering from gastric cancer. Full evaluation of new treatments of gastric cancer should be included patient-reported outcome measures such as health related quality of life (HRQOL) as well as assessment of biomarkers, pathologic responses or survival outcomes. A recent review of the literature on quality of life in gastric cancer indicated that in most reported studies quality of life was assessed mainly with generic measures, and the social dimensions of quality of life were largely neglected [3]. For instance the EORTC, in addition to core cancer quality of life questionnaire, has developed several site-specific questionnaires including gastric specific quality of life measures (the EORTC QLQ-STO22) in order to collect more relevant patient-reported outcomes in studying quality of life in this group of cancer patients
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