Abstract
Cerebral venous sinus thrombosis (CVST) causes significant problems for patients in the working age and may therefore negatively affect their quality of life (QOL). In the present study, we sought to evaluate the QOL and its predictors in subjects with CVST. This observational, prospective study investigated several outcomes of 56 CVST patients after thrombosis onset. Demographic characteristics, medical history, neurological signs and symptoms during hospitalization, and the employment status of the patients were retrospectively collected. Stroke-related functional scales, including the modified Rankin Scale (mRS) and Barthel Index (BI) were employed. For physical and mental aspects of the QOL, we used the validated Persian version of the Stroke Specific Quality of Life (SS-QOL) scale. The physical and functional outcomes in the long-term were promising according to mRS and BI tools, as well as the improved rate of return to work. Mental domains of the SS-QOL, such as energy and personality represented the lowest scores. According to the multiple linear regression analysis, lower mRS score, and longer time interval between CVST onset and interview were associated with higher physical function of the patients while their better mental function was correlated with lower mRS score and thrombosis in merely one cerebral venous. CVST patients experience an acceptable alleviation of the primary physical disabilities, while residual symptoms, mostly in psychologic/mental domains, impair their QOL.
Highlights
Cerebral venous sinus thrombosis (CVST) is a rare cerebrovascular event afflicting young people in the working age.[1,2] more than 90% of patients successfully recover from the acute phase, CVST still has extended effects on the lives of patients regarding their young age.[3]
We focused on the quality of life (QOL) of CVST patients and the factors that may influence it in the long-term
Our prospective observational long-term follow-up of 56 CVST patients demonstrated the relationship between CVST occurrence and different domains of life
Summary
Cerebral venous sinus thrombosis (CVST) is a rare cerebrovascular event afflicting young people in the working age.[1,2] more than 90% of patients successfully recover from the acute phase, CVST still has extended effects on the lives of patients regarding their young age.[3] CVST was primarily described in the early 19th century on post-mortem examinations. Until the publication of single-center and larger multicenter studies in the second half of the 20th century, there was no significant progress in understanding the pathophysiology and treatment of the disease.[3,4,5] Early investigations were focused on the acute phase of the disease and its mortality. The relationship between the hypothesized change in QOL and different demographic, neurological, and functional
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