Abstract
Objective. Most women with type I endometrial cancer (EC) are obese, increasing the risk of morbidity and mortality in this population. The study objective was to evaluate the impact of obesity on quality of life (QOL) and general health status in EC survivors with early-stage disease. Methods. A prospective ancillary analysis of stage I/II EC survivors. The association of BMI with QOL questionnaire variables measured with the functional assessment of cancer therapy (subscales: physical (PWB), functional (FWB), social, and emotional well-being) and the physical (PCS) and mental component summary subscales of the short-form medical outcomes survey was determined. Results. 152 women completed both questionnaires; 81% were obese. After multiple linear regression, BMI was inversely associated with PWB (P = .001), FWB (P = 0.048), and PCS (P = .001). Conclusions. Despite the good prognosis associated with early-stage EC, QOL, and physical health are not optimized in obese survivors. This paper highlights the importance of incorporating health-related QOL assessments and obesity interventions during the survivorship period.
Highlights
Outcomes research in the last decade has evolved beyond investigating conventional clinical endpoints to incorporating quality of life (QOL) endpoints, or direct assessments of how patients feel [1]
Apart from the impact Body mass index (BMI) had on perceived physical health and functioning in the current study, we demonstrated that morbid obesity in cancer survivors was significantly associated with fatigue
Our study demonstrated that the additive effects of obesity and age in elderly endometrial cancer survivors further decreased QOL scores
Summary
Outcomes research in the last decade has evolved beyond investigating conventional clinical endpoints to incorporating quality of life (QOL) endpoints, or direct assessments of how patients feel [1]. To that end, both the NCI and FDA have mandated that the goals of cancer therapies should be to improve both survival and QOL [1, 2]. Most women with endometrial cancer are overweight or obese and possess significant obesity-driven comorbidities that threaten their long-term health and QOL [4, 5]. Little is known about the effects of obesity on QOL and physical health of endometrial cancer survivors beyond the completion of therapy
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
