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Abstract
BackgroundInfantile hemangioma (IH) is the most common vascular tumor in children. It is controversial whether IHs has effects on the quality of life (QOL) in patients of whom IH poses no threat or potential for complication. Thus, we conducted this study to evaluate the q QOL in patients with IH and find the predictors of poor QOL.MethodsThe PedsQL 4.0 Genetic Core Scales and the PedsQL family information form were administered to parents of children with IH and healthy children both younger than 2-year-old. The quality-of-life instrument for IH (IH-QOL) and the PedsQL 4.0 family impact module were administered to parents of children with IH. We compared the PedsQL 4.0 Genetic Core Scales (GCIS) scores of the two groups. Multiple step-wise regression analysis was used to determine factors that influenced QOL in children with IH and their parents.ResultsExcept for physical symptom, we found no significant difference in GCIS between patient group and healthy group (P = 0.409). The internal reliability of IH-QOL was excellent with the Cronbach’s alpha coefficient for summary scores being 0.76. Multiple step-wise regression analysis showed that the predictors of poor IH-QOL total scores were hemangioma size, location, and mother’s education level. The predictors of poor FIM total scores were hemangioma location and father’s education level. The predictors of poor GCIS total scores were children’s age, hemangioma location and father’s education level.ConclusionThe findings support the feasibility and reliability of the Chinese version of IH-QOL to evaluate the QOL in children with IH and their parents. Hemangioma size, location and education level of mother are important impact factors for QOL in children with IH and their parents.
Highlights
Infantile hemangioma (IH) is the most common vascular tumor in children
We found the main influencing factors for The quality-of-life instrument for IH (IH-quality of life (QOL)) total scores included hemangioma location, hemangioma size and mother’s education level
Our results demonstrated that there was no significant difference in total score between IH patients and healthy children
Summary
Infantile hemangioma (IH) is the most common vascular tumor in children. It is controversial whether IHs has effects on the quality of life (QOL) in patients of whom IH poses no threat or potential for complication. Infantile hemangioma (IH) is the most common vascular tumor in children, with an estimated prevalence of 5 to 10%. The hemangioma lesions are small and pose no threat or potential for scarring and complication. Improvement in QOL of patients and their families is one of the most significant outcomes of treatment in pediatric tumors. The authors could not directly ask the patients and/or their parents about the influence of IHs. Studies using the generic QOL instruments have yielded conflicting results [6, 7]. By using a Dutch version of hemangioma-specific questionnaires, Wang et al Health and Quality of Life Outcomes (2017) 15:221
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