Abstract

A prospective study of the families of 35 children with intractable epilepsy who underwent epilepsy surgery at Sydney Children’s Hospital, NSW, Australia, found that those who were seizure-free had a greater improvement in the quality of life (QOL) than children with persistent seizures.

Highlights

  • A prospective, long-term population-based study was conducted to determine the evolution of drug resistance and remission in 144 patients with childhood-onset epilepsy followed at University of Turku, Finland, and Epilepsy Research Group, Berlin, Germany

  • At the end of 37-year follow-up since their first seizure before age 16 years, 67% were in terminal remission, on or off antiepileptic drugs

  • The course was remitting-relapsing before achieving terminal remission in 19%

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Summary

Introduction

A prospective study of the families of 35 children with intractable epilepsy who underwent epilepsy surgery at Sydney Children's Hospital, NSW, Australia, found that those who were seizure-free had a greater improvement in the quality of life (QOL) than children with persistent seizures. A prospective, long-term population-based study was conducted to determine the evolution of drug resistance and remission in 144 patients with childhood-onset epilepsy followed at University of Turku, Finland, and Epilepsy Research Group, Berlin, Germany. At the end of 37-year follow-up (range 11-42 years) since their first seizure before age 16 years, 67% were in terminal remission, on or off antiepileptic drugs.

Results
Conclusion

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