Quality of Life Assessment Using EuroQOL EQ-5D Questionnaire in Patients with Deep Infiltrating Endometriosis: The Relation with Symptoms and Locations.

C Touboul,M Bazot,E Daraï,A Fauconnier,P Amate,M Ballester

doi:10.1155/2013/452134

Abstract

The objective of this study was to evaluate the quality of life (QOL) of patients with deep infiltrating endometriosis (DIE) using EuroQOL (EQ-5D) and its correlation with symptoms and locations of endometriotic lesions. One hundred and fifty-nine patients referred for DIE from January 2011 to April 2011 were prospectively invited to complete questionnaires evaluating symptoms associated with endometriosis as well as the EQ-5D questionnaire and health state. Patients also had locations of DIE evaluated by clinical examination and magnetic resonance imaging (MRI). All 159 patients completed the questionnaires. Item response rate was 91.1%. The most intense symptoms were dysmenorrhea (7.1/10), painful defecation (6.3/10), and fatigue (6.0/10). Mean (SD) scores were 77 (14) for the EQ-5D questionnaire and 63.4 (21) for the health state. A relation was observed between the EQ-5D questionnaire and the presence of dysmenorrhea, dyspareunia, cyclic pelvic pain, painful defecation, and diarrhea or constipation. Vaginal and rectal infiltrations were significantly associated with altered EQ-5D and health state scores. The EQ-5D questionnaire is easy to complete and well related to symptoms of DIE. Rectal and vaginal infiltrations were found to be determinant factors of altered QOL by the EQ-5D questionnaire and health state.

Highlights

Endometriosis is a benign but potentially debilitating gynecologic disorder affecting 10% to 15% of patients during their reproductive life [1]
There are three types of endometriosis defined by the presence of endometrial glands and stroma outside the uterus: the peritoneal, the ovarian, or the deep infiltrating endometriosis (DIE); this latter type is characterized by involvement of organs and pelvic anatomic structures by endometriotic lesions
Sixty-four patients were excluded because they had already undergone a resection of DIE leaving a study population of 159 patients all of whom accepted to fill out the EQ-5D questionnaire

Summary

Introduction

Endometriosis is a benign but potentially debilitating gynecologic disorder affecting 10% to 15% of patients during their reproductive life [1]. It is a well-known cause of chronic pelvic pain, dysmenorrhea, and dyspareunia affecting quality of life (QOL) [2,3,4]. Specific multidimensional questionnaires to evaluate QOL in patients with endometriosis have been developed— by Bodner et al in 1997 [2], Colwell et al in 1998 [3], and Jones et al in 2001 [4]—but have only been validated in English.

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