Abstract
BackgroundAim of this multicenter, observational, cross-sectional study was to evaluate health-related quality of life (HRQoL) and treatment satisfaction of current medications in Chinese knee OA patients.MethodsBrief Pain Inventory (BPI), Treatment Satisfaction Questionnaire (TSQM-1.4), and HRQoL (EQ-5D-5L) were assessed in total of 601 OA of knee patients. Impact on QoL (EQ-5D-5L) and treatment satisfaction (TSQM-1.4) by BPI-Severity score (< 4 and ≥ 4) were presented using mean standard deviations (SDs) and were compared using a t-test. For each of self-assessed health EQ-5D-5L and TSQM, a linear regression model was used to estimate the regression coefficient along with corresponding 95% confidence interval (CI) for BPI-Severity.ResultsMean score of EQ-5D-5L of patients with BPI-Severity ≥4 was significantly lower than those with BPI-Severity < 4. All the scores of TSQM in 4 dimensions were lower in patients with BPI-Severity ≥4 than in those with BPI-Severity < 4. Both HRQoL scores and TSQM scores showed a statistically significant decreasing trend with increasing BPI-Severity pain score.ConclusionChronic knee OA pain has a significant impact on patients’ HRQoL. More severe patients with OA were less satisfied with current treatments.
Highlights
Aim of this multicenter, observational, cross-sectional study was to evaluate health-related quality of life (HRQoL) and treatment satisfaction of current medications in Chinese knee OA patients
Pain interfered with work productivity, with 37.1% of patients self-reporting that more than 4 days/week of work or housework were lost due to OA pain
The cross-sectional survey presented in this article is the first large-scale, multicenter real-world study to explore the impact of OA pain on HRQoL and treatment satisfaction among Chinese patients with OA]
Summary
Observational, cross-sectional study was to evaluate health-related quality of life (HRQoL) and treatment satisfaction of current medications in Chinese knee OA patients. Osteoarthritis (OA) is one of the most prevalent chronic musculoskeletal disorders and a leading cause of disability worldwide, especially among the elderly [1]. The guidelines recommend a stepwise approach for management of OA which include, a) basic treatment such as patient education (increase disease awareness, avoid bad life/work habit such as long-time running or jumping, avoid climbing stairs or mountains, lose weight), exercise therapy (lowintensity acrobatic exercise; muscle strengthening training; joint function training), physical therapy (heat, therapeutic cooling, acupuncture, massage) and motion assistance (cane, joint brace); b) medications (NSAIDs, glucocorticoid, sodium hyaluronate, symptomatic slowacting drugs for OA); and c) surgery [11]
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