Abstract
Quality of Life and Pituitary Function in Patients with Hereditary Hemochromatosis: An Observational Study
Highlights
Hereditary Hemochromatosis (HH) is a genetic disorder resulting in iron overload
In hereditary hemochromatosis phlebotomy is recommended to remove the excess iron that is toxic to cells
Increased iron deposits in the liver and pancreas may lead to cirrhosis, hypogonadotropic hypogonadism and diabetes
Summary
Hereditary Hemochromatosis (HH) is a genetic disorder resulting in iron overload. The HFE-gene related subtype 1 is the most common cause of HH in Northern Europe. There are no studies evaluating the influence of pituitary dysfunction and the quality of life in patients with HH [11]. We evaluated the association between the quality of life, ferritin and pituitary hormones in patients with HH. Alleviating the iron overload is believed to decrease the risk of complications including diabetes, osteoporosis and cirrhosis. It may reduce the risk of pituitary dysfunction. Hereditary Hemochromatosis (HH) can lead to complications including cirrhosis, diabetes and osteoporosis and pituitary dysfunction. Conclusion: This study found that a low ferritin may be having a detrimental effect on the quality of life in patients with HH.
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