Quality of life and handgrip strength of HIV patients diagnosed with neurotoxoplasmosis

Luiz Fernando Gouvêa-E-Silva,Cíntia Naira Souza De Lima,Marília Brasil Xavier,Silvania Yukiko Lins Takanashi,Kerolen Tayla Lima Fernandes

doi:10.1590/1980-0037.2019v21e59185

Abstract

Abstract HIV / AIDS epidemic continues to be a major public health problem, and when there is poor adherence to treatment, patients become susceptible to other infections such as toxoplasmosis. The aim of this study was to evaluate the handgrip strength and quality of life of HIV infected patients diagnosed with neurotoxoplasmosis. A cross-sectional study was conducted with 40 HIV-infected patients, with and without diagnosis of neuroxoplasmosis.Sociodemographic and clinical profile information was collected, and handgrip strength and quality of life were evaluated. Almost all patients of both groups used antiretroviral therapy. In the handgrip strength evaluation, no statistical difference was observed for the right and left hand between groups with and without neurotoxoplasmosis (p> 0.05). However, the classifica-1 Federal University of Pará. Gradution of inadequate handgrip strength in the neurotoxoplasmosis group was significantly higher.ate Program in Tropical Diseases. In the quality of life domain, it was observed that financial concern had lower scores in the Belém, PA. Brazil. group with neurotoxoplasmosis (p = 0.0379). It was observed that neurotoxoplasmosis showedno association with epidemiological, clinical, handgrip strength and quality of life variables.2 State University of Pará. Center However, patients with neurotoxoplasmosis showed a trend towards lower muscle strength.

Highlights

Human immunodeficiency virus (HIV) infection and its clinical manifestation in the advanced stage, or acquired immunodeficiency syndrome (AIDS) are still considered a public health problem of great relevance due to its pandemic character and its transcendence
Among the most common alterations in patients with AIDS, toxoplasmosis of the central nervous system caused by protozoan Toxoplasma gondii stands out, which is responsible for a large number of focal brain lesions[3]
The present study aimed to evaluate the handgrip strength and quality of life in HIV-infected patients diagnosed for neurotoxoplasmosis

Summary

Introduction

Human immunodeficiency virus (HIV) infection and its clinical manifestation in the advanced stage, or acquired immunodeficiency syndrome (AIDS) are still considered a public health problem of great relevance due to its pandemic character and its transcendence. Epidemiological Bulletin, from 2007 to June 2017, 194,217 cases of HIV infection were reported in Sinan in Brazil[1]. HIV mortality has greatly reduced with advances in antiretroviral therapy (ART), so a person can live 25 years or more. About 50% of all cases die from non-HIV-related causes. HIV cases are managed as a treatment for chronic disease with increased life expectancy, it may present multiple comorbidities[2]. Among the most common alterations in patients with AIDS, toxoplasmosis of the central nervous system caused by protozoan Toxoplasma gondii stands out, which is responsible for a large number of focal brain lesions[3]. Motor dysfunction caused by hemiparesis is due to muscle weakness, motor control, balance, sensory deficit and postural tone abnormalities[5]

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