Abstract
BackgroundPatient reported outcomes and costs of illness are useful to capture some of the multiple effects of a disease and its treatments. Our aim was to assess quality of life (QoL) and costs of Parkinson's disease (PD) in Hungary, and to analyze their associations.MethodsA cross-sectional questionnaire survey was conducted in one neurology university clinic. Clinical characteristics, PD related resource utilizations and productivity loss in the past 12 months were recorded; the Hoehn&Yahr (HY) scale, PDQ-39 and EQ-5D questionnaires were applied. Cost calculation was performed from the societal perspective.Results110 patients (34.5% female) were involved with mean age of 63.3 (SD = 11.3) and disease duration of 8.2 (SD = 5.8) years. PDQ-39 summary score was 48.1 (SD = 13.4). The average EQ-5D score was 0.59 (SD = 0.28), and was significantly lower than the population norm in age-groups 45–74. The correlation was significant between EQ-5D and PDQ-39 (−0.47, p = 0.000), the HY scale and EQ-5D (−0.3416, p = 0.0008) and PDQ-39 (0.3419, p = 0.0006) scores. The total mean cost was €6030.2 (SD = 6163.0)/patient/year (direct medical 35.7%, direct non-medical 29.4%, indirect cost 34.9%). A one year increase in disease duration and 0.1 decrease of the EQ-5D utility score increase the yearly costs by 8 to 10%, and 7.8%, respectively. The effect of the PDQ-39 score on total cost was not significant.ConclusionsDisease severity and public health importance of PD are clearly demonstrated by the magnitude of QoL loss. PD-related costs are substantial, but are much lower in Hungary than in Western European countries. Disease duration and EQ-5D score are significant proxy of costs.
Highlights
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders [1]
We found significant differences in EQ-5D, EQ VAS and PDQ-39 scores between the HY category I and II (p,0.01)
We found a significant moderate correlation between the EQ-5D and EQ VAS scores (0.49; p = 0.000) as well as between EQ-5D and PDQ-39 scores (20.47; p = 0.000)
Summary
In Hungary, about 20 000 people live with PD [2]. Over the past two years, cost of illness studies from various European countries have been reported that PD related costs substantially vary from country to country [3,4,5,6,7]. Our aim was to provide evidence on health-related quality of life (HRQL) of patients with PD and cost of illness in Hungary, and to analyze the relationship between diverse health measures and costs. Patient reported outcomes and costs of illness are useful to capture some of the multiple effects of a disease and its treatments. Our aim was to assess quality of life (QoL) and costs of Parkinson’s disease (PD) in Hungary, and to analyze their associations
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