Abstract
The article studies the influence of hymatomelanic acids, one of the fractions of humic substances of peloids, on the course of rheumatoid arthritis. This substance was standardized by using physicochemical analysis. The elemental composition of the substance as well as a number of spectral (IR, NMR) characteristics were revealed. The list of components formed as a result of hydrolysis of the initial preparation and their relative content was determined. Fatty acids and their derivatives are the predominant constituents of peloid hymatomelanic acid hydrolyzate. The tissues of immunocompetent organs including regional lymph nodes, spleen, and also rat liver were studied. For the experiment, a model of adjuvant arthritis was selected and four groups of animals were formed. They were withdrawn from the experiment on the 17, 21 and 26 day. The histological picture indicated that when modeling rheumatoid arthritis, such pathological changes in the immunocompetent organs of rats as edema of the parenchyma and stroma, sclerosis, thickening of the walls of blood vessels, develop during the whole period of observation. A list of descriptors of the studied drug was obtained and it was found that the use of peloid himatomelanic acids in the model of adjuvant arthritis had a pronounced anti-inflammatory effect, as evidenced by the normalization of the morphofunctional state of the spleen, regional lymph nodes and liver.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
