Abstract
Introduction: hydrochlorothiazide is a diuretic drug indicated for the continuoustreatment of hypertension. The drug is presented as a medicine in the form of tabletscontaining only one active agent or combined in formulations with concentrationsof 12.5, 25 and 50 mg. The 25 mg dosage is the most widely used in medical therapy.Therefore, considering the incidence of hypertension and prolonged use of the drug, it isnecessary to determine the quality of hydrochlorothiazide tablets available on public andprivate pharmacies of Salvador, Bahia. Complaints regarding the compromised qualityof the products stored in drugstores are reported very often. Material and Methods:following the drug monograph, and consequently the pharmacopoeial methods, thisstudy aimed to carry out quality control, physicochemical and microbiological testingof medicines containing hydrochlorothiazide, including the trade name (reference – R),generic (G) and similar (S) medicine, which is provided by National Health Service(aka SUS – Sistema Único de Saúde). Results: it was observed that the samples of themedicines: R, G and S samples showed complies with the pharmacopoeial tests, exceptfor the assay of generic which content presented out of specification.
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