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Abstract
BackgroundPolygoni Multiflori Caulis, the dried caulis of Polygonum multiflorum Thunb., is one of the commonly used traditional Chinese medicines having antioxidant, anti-obesity, anti-inflammatory and antibacterial effects. Polygoni Multiflori Caulis used clinically or circulated on market have great differences in their diameters. However, to the best of our knowledge, no study has been reported on the qualities of Polygoni Multiflori Caulis with different diameters.ResultsSystematic HPLC/UV/MS chromatographic fingerprinting and quantitative analytical methods combined with principal component analysis were developed and applied to analyze different Polygoni Multiflori Caulis samples. The contents of 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside, the chemical marker for quality control on Polygoni Multiflori Caulis specified in Chinese Pharmacopoeia (2010 edition), were found to have surprising relevance with the samples’ diameters for the first time.ConclusionThe finding provides a scientific basis for collecting Polygoni Multiflori Caulis in the best time. Moreover, the diameter can be used as the criterion for quality control on Polygoni Multiflori Caulis as a preliminary step in the future. In addition, scores plot obtained from principal component analysis shows the obvious differences between unqualified Polygoni Multiflori Caulis samples and qualified ones visually, which can be used to single out the unqualified ones with qualified ones efficiently and immediately.
Highlights
Polygoni Multiflori Caulis, the dried caulis of Polygonum multiflorum Thunb., is one of the commonly used traditional Chinese medicines having antioxidant, anti-obesity, anti-inflammatory and antibacterial effects
We found that the contents of THSG had great relevance with the diameters of Polygoni Multiflori Caulis (PMC) samples
The results indicated that emodin and physcion were not the dominant chemical compounds in PMC compared with THSG
Summary
Polygoni Multiflori Caulis, the dried caulis of Polygonum multiflorum Thunb., is one of the commonly used traditional Chinese medicines having antioxidant, anti-obesity, anti-inflammatory and antibacterial effects. Polygoni Multiflori Caulis used clinically or circulated on market have great differences in their diameters. To the best of our knowledge, no study has been reported on the qualities of Polygoni Multiflori Caulis with different diameters. Polygoni Multiflori Caulis (PMC), Shou-Wu-Teng in Chinese, is the dried caulis of Polygonum multiflorum Thunb. It is one of the commonly used traditional Chinese medicines (TCMs) listed in Chinese Pharmacopoeia (CP) (2010 edition) [1]. Unlike Polygoni Multiflori Radix, He-Shou-Wu in Chinese, there are only a few reports on quality control of PMC. High performance liquid chromatography (HPLC) with ultraviolet detector (UV) were applied to determine the contents of 2,3,5,4′-tetrahydroxystilbene-2-O-β-Dglucoside (THSG) and emodin [8,9,10], but THSG, one of the stilbene glycoside, was not specified as chemical marker for quantitative determination of PMC until CP (2010 edition) was published
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