Abstract
Patients with pharyngitis often describe various sensory, affective and evaluative pain qualities. Using an 11-word/phrase index, the Qualities of Sore Throat Index (QuaSTI), we characterized throat symptoms and evaluated changes in a randomized controlled trial (NCT01986361). Patients received a single flurbiprofen 8.75mg (n=101) or placebo (n=21) lozenge and rated throat soreness at baseline and regular intervals over 3h, and the QuaSTI at baseline, 1, 2 and 3h post-treatment. The QuaSTI distinguished active drug from placebo and detected clinically important (≥2-point) changes over 3h. Mean change from baseline over 3h was significantly greater for flurbiprofen (154%) than placebo (p<0.05). The QuaSTI is a sensitive instrument for measuring therapeutic effects in patients with pharyngitis.
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