Abstract
The tissue reaction of bone tissue accessed by light microscopy and scanning electron microscopy (SEM) images after polyurethane resin implantation is presented in this study. Twenty four male rabbits were used, divided into two groups of 12 animals each (experimental group and control group) in which full-thickness cranial defect was surgically created. At 30 and 90 days post operation 6 animals of each group were euthanized and bone samples were removed for analysis. The microscopic results indicated no inflammatory foreign body reaction, a perfect union between the polymer and surgical bone bed surface, lack of bone resorption and presence of a thin layer of osteogenic material covering the polymer surface in contact with the surgical bone bed. The SEM images demonstrate the porosity of the resin, with diameters from 120 to 500 µm. This important feature of this polymer is associated with its osteoconductivity, allowing the bone growth inside it, improving the integration between the material and bone tissue. These results confirm that polyurethane resin derived from Ricinuscommunis is an excellent bone substitute for use in repair surgery for great bone losses.
Highlights
Extensive bone defects resulting from surgery, traumaNumerous synthetic bone promoting biomaterials such and congenital anomalies continue to pose significant as: tricalcium phosphate[12,13], porous hydroxyapatite[14], reconstructive problems
Examples of injectable scaffold currently gradually substituted by the bone tissue in formation) available for bone regeneration include Acrylic Bone osteoconductive and, if possible, must possess Cements (ABCs), Calcium Phosphate Cements (CPCs), T
The most attractive aspect is the close link of the polyurethane resin to the surgical bone bed surface
Summary
Extensive bone defects resulting from surgery, traumaNumerous synthetic bone promoting biomaterials such and congenital anomalies continue to pose significant as: tricalcium phosphate[12,13], porous hydroxyapatite[14], reconstructive problems. In defects reconstruction there biopolymer[15,16,17] and bioactive glass[18,19] have been is a need for creating conditions to the stimulus of bone developed In this context, injectable scaffolds represent neoformation in order to avoid the fibrous connective a very interesting option because they are adapted tissue growth into the bone defect, which would hinder in the shape of defect, allowing the tissue repair after osteogenesis. Injectable scaffolds represent neoformation in order to avoid the fibrous connective a very interesting option because they are adapted tissue growth into the bone defect, which would hinder in the shape of defect, allowing the tissue repair after osteogenesis For this reason numerous biologically minimally invasive administration. Examples of injectable scaffold currently gradually substituted by the bone tissue in formation) available for bone regeneration include Acrylic Bone osteoconductive and, if possible, must possess Cements (ABCs), Calcium Phosphate Cements (CPCs), osteoinductive property[5]
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