Abstract
Polymorphism is an important characteristic of pharmaceutical products because different polymorphs exhibit different physicochemical stabilities, dissolution rates, etc., which makes them different in therapeutic efficiency. Thus, it is important to control the polymorphic structure of pharmaceutical products. A spectroscopy method based on Fourier transform near infrared (FT-NIR) spectroscopy and chemometric techniques is introduced to classify paracetamol preparations according to polymorphic changes. X-ray diffraction (XRD) and FT-NIR studies were carried out on standard samples, paracetamol preparations (acetaminophen tablet), and also the additives. A direct comparison was performed between the spectroscopic data and those obtained by XRD. The NIR and XRD analyses of paracetamol preparations show some distinct differences, particularly in the Iranian tablet. These differences are found to be related to polymorphism and paracetamol purity. The cluster analysis (CA) and principal component analysis (PCA) were utilized to classify the paracetamol preparations. FT-NIR spectroscopy provides a simple, rapid and accurate qualitative analysis method for the identification of paracetamol polymorphs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
