Abstract
Effects of qualitative and quantitative differences in dietary poteins on hyperlipidemia and proteinuria were studied in rats with nephrotoxic serum nephritis. Dietary proteins examined were milk casein, whole egg protein, soy protein isolate and wheat gluten. Rats were maintained on experimental diets for 14 days after an injection of nephrotoxic serum to induce nephritis. In the qualitative study, almost the same extent of growth and urinary protein excretion was observed in a 20% casein (20C), egg protein (20E) and a soy protein (20S) group. Growth and protein excretion of a 20% gluten (20G) group were suppressed compared with that of the other three groups. The serum lipid levels were highest in the 20E group and lowest in the 20G group. In the quantitative study, 8.5% protein diets, in general, ameliorated hyper lipidemia and proteinuria but retarded the growth of rats compared with the corresponding 20% protein diets, except for an 8.5% egg protein diet that did not suppress the growth. These results suggest that amino acid-balanced low protein diets improve hyperlipidemia and proteinuria without growth retardation in nephritic rats.
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