Abstract
Qualitative and Quantitative Determination of Organic Acids in Crude Herbal Drugs and Medicinal Herbal Preparations for Quality Control in Russian Federation by Modern Physicochemical Methods
Highlights
The current level of natural biologically active substances (BAS) analysis, as well as issues related to the development and improvement of standardization procedures, requires the use of exact physicochemical methods in quality control of crude herbal drugs
The determination of ascorbic acid in crude herbal drugs is recommended to be carried out by titration with a solution of 2,6-dichloroindophenol sodium salt according to the method of the State Pharmacopoeia of Russian Federation XI edition (SPRF XI) of the monograph “Rosae fructus”
Galvanostatic coulometry was performed with the help of the “Expert-006” coulometer (Econix-Expert, Russia) with a current of 5 mA16 Iodine as an electrogenerated titrant was used for ascorbic acid determination
Summary
The current level of natural biologically active substances (BAS) analysis, as well as issues related to the development and improvement of standardization procedures, requires the use of exact physicochemical methods in quality control of crude herbal drugs. Organic acids, (OA: malic, citric, tartaric, oxalic, acetic, formic, isovaleric, ascorbic acids) make up a large group of BAS and play an important role in plant metabolism. Organic acids (malic, citric, tartaric, oxalic, acetic, formic, isovaleric, ascorbic acids) make up a large group of biologically active substances and play an important role in plant and human metabolism. They are found in large quantities in the fruits of Rosaceae family medicinal plants that included in State Pharmacopoeia of the Russian Federation. Results: Modern physicochemical methods for the analysis of biologically active substances, organic acids, for quality control of crude herbal drugs and medicinal herbal preparations, are developed and discussed.
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