Abstract
The present pharmacotherapy for eosinophilic esophagitis (EoE) fundamentally depend on inhaled corticosteroids. Despite the fact that oral intake of topical steroids can be successful in restricting EoE-related inflammation, there are concerns with respect to the long term utilization of steroids, especially in kids. In the current research, we assess the effect of quail egg, which is reportedly a known serine protease inhibitor, on symptomatology and immune responses in a peanut-sensitized mouse model of food allergy induced EoE. Daily oral treatment with quail egg attenuated mice symptomatology and immune response. Treatment with quail egg inhibited antigen-prompted increments in mouse tryptase and eosinophil cationic protein (ECP) in serum and eosinophil in inflamed tissues like oesophagus, lung, and digestive system. Quail egg treatment resulted in decreased antibody specific IgE and IgG1 and a variety of inflammatory genes that were abnormally expressed in EoE. Other effects included increased IL-10, decreased PAR-2 activation and NF-kB p65 in inflamed tissues. Our results suggest that quail egg treatment may have therapeutic potential in attenuating the symptoms of food allergy induced EoE like disease through regulating PAR-2 downstream pathway by blocking the activation of the transcription factor NF-kB p65 activity.
Highlights
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease associated with food allergy[1,2,3] which seriously affects the patient’s normal life
In order to determine whether the quail egg could alleviate the food allergy induced eosinophilic esophagitis (EoE) like disease symptoms, we conducted observations on the systemic and local allergic reactions of mice within 40 min after skin or intragastric challenge
Compared to control group (C group), the body temperature of P mice group dropped by 6.50 ± 0.76 °C (P < 0.05) while after giving oral quail egg treatment, the drop observed in protein peanut extract (PPE) sensitized group treated with quail egg (P + Q group) was lower, with a drop of 2.00 ± 0.56 °C (P < 0.05)
Summary
Eosinophilic esophagitis (EoE) is a chronic inflammatory disease associated with food allergy[1,2,3] which seriously affects the patient’s normal life. There is a pressing need to find and create novel and powerful anti-inflammatory drugs for EoE It was revealed in a previous study that quail egg is different from other bird eggs. The role of quail egg has been determined in the context of allergic asthmatic[12,13] and rhinitis[14] treatments, but not in food allergy, its role in the treatment of food allergy induced EoE like disease has not been reported previously. This study used mouse model of peanut allergen induced EoE like disease to study the anti-inflammatory and anti-allergic effects of quail egg and its mechanism in treating food allergy
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