Quadruple Therapy Is an Effective Salvage Regimen for Helicobacter Pylori Infection in Patients After Failure of Standard Triple Therapy - Comparison of OMBT 7, 14 Days Regimen -

Abstract

Backgrounds/Aims. At present, triple therapy schemes are recommended by national and international consensus conferences. But, even with the currently most effective treatment regimens, about 10-20% of patients will fail to obtain eradication of Helicobacter pylori infection. Therefore, We need adequate strategy for primary therapy failed patients and so, we are about to evaluate the efficacy of the quadruple therapy and compare 7- with 14- day quadruple regimens in second-line treatment. Methods: Seventy one consecutive patients who failed to respond to standard triple therapy(clarithromycin, amoxicillin, PPI) were randomly assigned to a OMBT(omeprazole 20 mg b.d., metronidazole 500 mg t.d.s., bismuth salt 120 mg q.d.s., tetracycline 500 mg q.d.s.) 7 or 14 days regimen. H. pylori status and side-effects were assessed 4 weeks after treatment. Results: 51 male and 20 female (mean age, 50.6) patients were enrolled. The overall eradication rate of H. pylori in quadruple therapy was 83.1% and the eradication rate was higher in OMBT 14 days regimen than 7 days regimen ( 88.9% in OMBT 14 days, 73.1% in OMBT 7 days, respectively p = 0.089). Comparison of side-effects in two groups were not significance. Conclusions: Quadruple therapy is an effective salvage regimen for H. pylori infection after failure of standard triple therapy and 14 days quadruple therapy are better than 7 days regimen as second-line option for H. pylori eradication.