Abstract
Background: Methods which potentially could prevent age-related loss of muscle mass and function are still being sought. There are various attempts to use pharmacological agents to prevent loss of muscle mass, but the effectiveness of many of them still needs to be confirmed. One of the promising therapeutics are Angiotensin Converting Enzyme Inhibitors (ACEIs) and lowering of serum ACE activity. The goal of this study was to assess if taking Angiotensin Converting Enzyme Inhibitors (ACEI) and other angiotensin system blocking medications (ASBMs) can modify muscle performance in older men as well as to assess the association of serum ACE activity with muscle strength, power, muscle contraction velocity and functional performance. Methods: Seventy-nine older men took part in the study. Muscle function was assessed with hand grip strength, maximum power relative to body mass (Pmax) and optimal shortening velocity (Ʋopt) of the knee extensor muscles. Anthropometric data, ACE activity and functional performance were also measured. Results: Negative correlations between ACE activity and Pmax (rho=-0.29, p=0.04) as well as Ʋopt (rho=-0.31, p=0.03) in a group of patients not taking ACEI and between ACE activity and Ʋopt (rho=-0.22, p=0.05) in the whole group of men were found. Positive relationship between age and ACE activity was demonstrated (rho=0.26, p=0.02). Age was the only selected variable in the multiple regression analyses to determine both Pmax and Ʋopt. Conclusions: Taking ACEI is not associated with a functional performance in older men of the same age and with the same anthropometric parameters. Serum ACE activity negatively associates to muscle power and muscle contraction velocity.
Highlights
Age-related sarcopenia, connected with deteriorating in muscle mass and function, is one of the most important factors determining functional status[1,2,3]
The goal of our study was to assess if taking Angiotensin Converting Enzyme Inhibitors (ACEI) can modify muscle performance in older man as well as to assess the association of serum angiotensin-converting enzyme (ACE) activity with muscle strength, power, muscle contraction velocity and functional performance
We have found a negative correlation between ACE activity and maximum power (Pmax) (Figure 1) as well as with Ʋopt (Figure 2) in group of patients not taking ACEI and in the whole group of men (Table 2)
Summary
Age-related sarcopenia, connected with deteriorating in muscle mass and function, is one of the most important factors determining functional status[1,2,3]. One sentence requires an explanation: ○ "Taking ACEI as well as the ACE genotype with insertion (II) of allele in gene, is associated with lower serum ACE activity and with predispositions for practicing some sports." – there is no evidence, that taking ACEI is associated with predispositions for practicing some sports (there are some reports about the ACE genotype) - this sentence suggests such a relationship Please formulate this sentence in a different way. The goal of this study was to assess if taking Angiotensin Converting Enzyme Inhibitors (ACEI) and other angiotensin system blocking medications (ASBMs) can modify muscle performance in older men as well as to assess the association of serum ACE activity with muscle strength, power, muscle contraction velocity and functional performance.
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