Abstract
Several reports have suggested the role of methadone in QT prolongation, Torsades de Pointes (TdP), and ventricular arrhythmia. The aim of this study was to identify the frequency of QT interval prolongation and QT dispersion among a population of addict patients treated with methadone, completed by the description of cardiac events reported to the French pharmacovigilance system. QT interval (corrected with the Bazett's method) and dispersion were measured on a cohort of patients treated with methadone during their visit to addiction specialized centers in Southwest of France. Whenever possible, methadone blood concentrations were measured. In addition, reports concerning methadone were searched in the French Pharmacovigilance database from 1996 to 2007. The cohort included 42 patients with mean QTc length of 414.3 ± 28.5 ms and mean QT dispersion of 66.0 ± 41.1 ms. None of the patient presented a QTc above 500 ms. These values were higher in patients with recent increase in methadone dose, use of tobacco or drugs prolonging QT, and history of cardiac disease. We found five cases of QT prolongation (3 TdP) and seven cases of sudden deaths in the French pharmacovigilance database (2.2% of methadone reports). Most of these events occurred after introducing methadone or another drug potentially interacting with methadone. Methadone can prolong the QT interval at dose usually used for addiction maintenance treatment in France. A cardiac evaluation, with at least a systematic ECG, could be useful during methadone treatment, particularly in case of recent modification of the regimen.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.