QT Interval Prolongation and Torsades De Pointes Due to a Coadministration of Ciprofloxacin and Azimilide in a Patient with Implantable Cardioverter–Defibrillator

Abstract

The presented case report describes a male patient with an implanted cardioverter-defibrillator (ICD) in whom a coadministration of ciprofloxacin and azimilide caused QT interval prolongation and multiple episodes of torsades de pointes (TdP) followed by ICD shocks (arrhythmic storm). The case highlights a not described drug interaction between azimilide and ciprofloxacin, which is believed to be the safest member of fluoroquinolones class.