QT and corrected QT parameters in non-obese young Indian women with polycystic ovary syndrome

Abstract

Background: Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age group. The QTc interval duration, which is related to cardiac arrhythmia, sudden death and a sign of cardiac autonomic neuropathy, has not been investigated thoroughly in PCOS population. Objectives: The aim of the present study was to investigate the potential alterations in electrocardiographic (ECG) – QT parameters in lean and ideal weight young Indian patients with PCOS. Materials and Methods: 24 classical PCOS diagnosed by Rotterdam 2003 Diagnostic criteria and were lean or ideal weight as per WHO criteria and 24 BMI matched, age matched normally menstruating women served as study participants. All of them underwent assessments clinically and by appropriate laboratory tests. We assessed metabolic pattern and performed ECG analysis for evaluating QT interval, minimum and maximum QT interval (QT Max and QT Min), QT dispersion (QTd), minimum and maximum QT interval corrected for heart rate (QTcmin and QTcmax, respectively), corrected QT dispersion (QTcd) and QT/QTc ratio. Results: QT (388 ± 35 vs 431 ± 53 ms , P value < 0.01) ; QTmax (427 ± 46 vs 467 ± 64ms, P value