QSDB-a graphical Quorum Sensing Database.

Karsten Klein,Sina Rütschlin,Thomas Böttcher,Dimitar Garkov,Falk Schreiber

doi:10.1093/database/baab058

Karsten Klein, Sina Rütschlin + Show 3 more

Open Access

https://doi.org/10.1093/database/baab058

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Abstract

The human microbiome is largely shaped by the chemical interactions of its microbial members, which includes cross-talk via shared signals or quenching of the signalling of other species. Quorum sensing is a process that allows microbes to coordinate their behaviour in dependence of their population density and to adjust gene expression accordingly. We present the Quorum Sensing Database (QSDB), a comprehensive database of all published sensing and quenching relations between organisms and signalling molecules of the human microbiome, as well as an interactive web interface that allows browsing the database, provides graphical depictions of sensing mechanisms as Systems Biology Graphical Notation diagrams and links to other databases. Database URL: QSDB (Quorum Sensing DataBase) is freely available via an interactive web interface and as a downloadable csv file at http://qsdb.org.

Highlights

The microbiome is gaining increasing attention, and its balanced composition is of importance for human health and disease [1, 2]
Diverse microbial population behaviours as well as many important microbe–microbe and microbe–host interactions are coordinated by diffusible signalling molecules in a process known as quorum sensing (QS)
QS allows microbes to coordinate their behaviour in dependence of microbial population density by regulating gene expression

Summary

Introduction

The microbiome is gaining increasing attention, and its balanced composition is of importance for human health and disease [1, 2]. Diverse microbial population behaviours as well as many important microbe–microbe and microbe–host interactions are coordinated by diffusible signalling molecules in a process known as quorum sensing (QS). Understanding the complex cross-talk, eavesdropping and antagonism within species of the human microbiome requires a qualitative global view of the distribution and diversity of QS systems, as well as detailed information on the ability of microbes to produce, sense or quench these signals [10].

Results

Conclusion