Abstract
The paper deals with quantitative structure–activity relationship (QSAR) study on CA inhibitory activity (log IC 50) of disulfonamides using a large series of distance-based topological indices. The study discusses effect due to halogen-substitution nearer ( o-position) to –SO 2NH 2 groups. The results have shown that halogen substitution at R 3 has pronounced effect on the inhibitory activity. Predictive power of the proposed models is discussed on the basis of regression data and cross-validation parameters.
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